Glad your daughter finds relief with mast cell stabilizers that don’t have anticholinergic effects. I personally didn’t have much luck with mast cell stabilizers (Claritin, Allegra, Zyrtec, Cromolyn, rutin, bromelein, luteolin, cocoa flavanols, etc), but quercetin really helped alleviate my breathing distress when I first developed COVID pneumonia. I hypothesize that inappropriate mast cell degranulation is triggered by gut dysbiosis, which initiates inflammatory cytokine production and the subsequent release of histamine, tryptase, heparin, and other substances.
The gut bacteria also play significant roles in bone deposition and skeletal development. Here’s a couple papers from the Novince laboratory at MUSC examining the impact of antibiotics and segmented filamentous bacteria (SRB), respectively, on postpubertal skeletal maturation:
https://asbmr.onlinelibrary.wiley.com/doi/full/10.1002/jbm4.10338
Sometimes I wonder if the antibiotics I took during early childhood for repeated bouts of pneumonia affected my skeletal development negatively by disrupting normal gut microbiota-osteoimmune crosstalk and predisposed me to chondromalacia and hypermobility. Like you mentioned, a genetic signature for hEDS has yet to be found. Perhaps the cause is more microbial.
